ANTICANCER DRUGS
DRUGS ACTING DIRECTLY ON CELLS (CYTOTOXIC DRUGS)
1. Alkylating Agents
a. Nitrogen mustards
Melphalan
Mechlorethamine (Mustine HCl)
Cyclophosphamide
Ifosfamide
Chlorambucil
b. Ethylenimine
Thio-TEPA
c. Alkyl sulfonate
Busulfan
d. Nitrosoureas
Carmustine
Lomustine
e. Triazine
Dacarbazine
Temozolomide
f. Methyl hydrazine
Procarbazine
2. Antimetabolites
a. Folate antagonist
Methotrexate
b. Purine Antagonist
6-Mercaptopurine
6-Thioguanine
Azathioprine
Fludarabine
c. Pyrimidine Antagonist
5-Fluorouracil
Cytarabine
Capecitabine
3. Microtubule Damaging Agents
a. Vinca alkaloids
Vincristine
Vinblastine
b. Taxanes
Paclitaxel
Docetaxel
c. Others
Estramustine
4. Epipodophyllo Toxin(Topoisomerase-2 inhibitor)
Etoposide
5. Camptothecin Analogues (Topoisomerase-1 inhibitor)
Topotecan
Irinotecan
6. Antibiotics
Actinomycin D
Doxorubicin
Daunorubicin
Epirubicin
Mitoxantrone
Bleomycins
Mitomycin C
7. Miscellaneous
Hydroxyurea
L-Asparaginase
Tretinoin
Arsenic trioxide
TARGETED
DRUGS
a. Tyrosine protein kinase inhibitors
Imatinib
Nilotinib
b. EGF receptor inhibitors
Gefitinib
Erlotinib
Cetuximab
c. Angiogenesis Inhibitors
Sunitinib
Bevacizumab
d. Proteosome inhibitor
Bortezomib
e. Monoclonal Antibody
Rituximab
DRUGS
ALTERING HORMONAL MILIEU
a. Glucocorticoids
Prednisolone and others
b. Estrogens
Fosfestrol
Ethinylestradiol
c. Selective estrogen receptor modulators
Tamoxifen
Toremifene
d. Selective estrogen receptor down regulator
Fulvestrant
e. Aromatase inhibitors
Letrozole
Anastrozole
Exemestane
f. Antiandrogen
Flutamide
Bicalutamide
g. 5-α reductase Inhibitors
Finasteride
Dutasteride
h. GnRH analogues
Naferelin
Triptorelin
i. Progestins
Hydroxyprogesterone caproate