AUTOCOIDS & RELATED DRUGS (MCQ’s)

✽   Autacoids differ from hormones in
     (a) Autacoids are involved only in the causation of pathological states
     (b) Autacoids do not have a specific cell/tissue of origin
     (c) Autacoids generally act locally at the site of generation and release
     (d) Both ‘B’ and ‘C’ are correct

ANSWER:  [  d  ] 

✽   Which of the following is a selective H1 receptor agonist
     (a) 4-methyl histamine
     (b) Impromidine
     (c) 2-Thiazolyl ethylamine
     (d) Chlorpheniramine

ANSWER:  [  c  ] 

✽   The action of histamine that is not mediated through H1  receptors is
     (a) Release of EDRF from vascular endothelium resulting in vasodilatation
     (b) Direct action on vascular smooth muscle causing vasodilatation
     (c) Bronchoconstriction
     (d) Release of catecholamines from adrenal medulla

ANSWER:  [  b  ] 

✽   Histamine exerts the following actions except
     (a) Dilatation of large blood vessels
     (b) Dilatation of small blood vessels
     (c) Stimulation of isolated guineapig heart
     (d) Itching

ANSWER:  [  a  ] 

✽   Fall in blood pressure caused by larger doses of histamine is blocked by
     (a) H1 antihistaminics alone
     (b) H2 antagonists alone
     (c) Combination of H1 and H2 antagonists
     (d) None of the above

ANSWER:  [  c  ]