HORMONES & RELATED DRUGS

✽   Gonadotropins are indicated in the following conditions except
     (a) Hypogonadotrophic hypogonadism in males
     (b) Cryptorchism in a boy less than 7 years old
     (c) Amenorrhoea and infertility in women
     (d) Polycystic ovaries

ANSWER:  [  d  ] 

✽   The hypothalamic gonadotropin releasing hormone (GnRH) is
     (a) A single peptide
     (b) A mixture of two distinct peptides FSH-RH and LH-RH
     (c) A mixture of several peptides
     (d) Dopamine

ANSWER:  [  a  ] 

✽   Menotropins is a preparation of
     (a) FSH + LH obtained from urine of menstruating women
     (b) LH obtained from urine of pregnant women
     (c) FSH + LH obtained from urine of menopausal women
     (d) LH obtained from serum of pregnant mare

ANSWER:  [  c  ] 

✽   Gynaecomastia can be treated with
     (a) Chlorpromazine
     (b) Cimetidine
     (c) Bromocriptine
     (d) Metoclopramide

ANSWER:  [  c  ] 

✽   The most prominent action of bromocriptine is
     (a) Dopamine D2 agonism
     (b) Dopamine D2 antagonism
     (c) Dopamine D1 antagonism
     (d) α adrenergic antagonism

ANSWER:  [  a  ] 

✽   Bromocriptine causes the following
     (a) Prolactin release
     (b) Vomiting
     (c) Uterine contraction
     (d) Impotence

ANSWER:  [  b  ] 

✽    Hyperprolactinemia can cause the following except
     (a) Amenorrhoea
     (b) Gynaecomastia
     (c) Multiple ovulation
     (d) Depressed fertility

ANSWER:  [  c  ] 

✽    For therapeutic use, growth hormone is obtained from
     (a) Recombinant DNA technique
     (b) Human cadaver pituitaries
     (c) Porcine pituitaries
     (d) Chemical synthesis

ANSWER:  [  a  ] 

✽   Drugs that suppress growth hormone release in acromegaly include the following except
     (a) Bromocriptine
     (b) Somatostatin
     (c) Octreotide
     (d) Nafarelin

ANSWER:  [  d  ] 

✽    Indications of somatostatin include
     (a) Macroprolactinoma
     (b) Zollinger Ellison syndrome
     (c) Bleeding esophageal varices
     (d) Steatorrhoea

ANSWER:  [  c  ] 

✽   Somatostatin inhibits the release of
     (a) Growth hormone
     (b) Insulin
     (c) Thyrotropin
     (d) All of the above

ANSWER:  [  d  ] 

✽   Octreotide is a long acting synthetic analogue of
     (a) Prolactin
     (b) Growth hormone
     (c) Somatostatin
     (d) Gonadotropin releasing hormone

ANSWER:  [  c  ] 

✽  Several actions of growth hormone are exerted through the elaboration of
     (a) Cyclic AMP
     (b) Cyclic GMP
     (c) Somatostatin
     (d) Insulin like growth factor-1

ANSWER:  [  d  ] 

✽   The following hypothalamic regulatory hormone is not a peptide
     (a) Growth hormone release inhibitory hormone
     (b) Prolactin release inhibitory hormone
     (c) Gonadotropin releasing hormone
     (d) Corticotropin releasing hormone

ANSWER:  [  b  ] 

✽   Which hormone acts through a cytoplasmic receptor
     (a) Calcitriol
     (b) Prolactin
     (c) Vasopressin
     (d) None of the above

ANSWER:  [  a  ] 

✽   Actions of growth hormone include the following except
     (a) Increased protein synthesis
     (b) Increased fat utilization
     (c) Increased carbohydrate utilization
     (d) Glucose intolerance

ANSWER:  [  c  ]